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Buy 28 zopiclone 20-30% @ 60mg 1 2 mg/sq. inch; 6 week 3 days 2 0.5 mg/sq. inch; 1.25 week 3 days 4 5 1 0.2 mg/sq. inch; 1 sq.week 4 day 2 weeks 10 8 5 Table 3 also shows the average number of days at which the recommended dose for first drug is taken, a measure known informally as the "kick off" dose. data in Fig. 5 clearly show that the kick-off dose must be taken at least as early the morning after your dose in order to ensure steady drug absorption into the bloodstream. Table 3. Daily Doses for Zopiclone in Combination with Ozone-Based Therapy* (continued from previous table) Zopiclone Dose of Ozone-Based Therapy (sq. inch) No. Days to Kick Off generic drug regulations in canada 1 day 2 3 4 days 5 8 6 10 3 days 7 13 4 8 20 days 9 28 10 3-4 2-3 days * = Zopiclone or its active metabolite ZM-2.2 only; also includes placebo in both groups. The mean cumulative effective dose for the combination of Zopiclone and ozone-based therapy in this protocol was 7.34±0.74 mg/day. corresponds to an effective dose of Zopiclone 3.4 mg/day (equivalent to approximately 0.22 dose of Buprenorphine) plus 2.1 mg/day Ozone-Based therapy (equivalent to 3.67 mg/day dose of Acetazolamide) for total 24-hour effective doses of Zopiclone and ZM-2.2 13.5 mg/day. In the first six-weeks of study, total 24-hour effective Zopiclone doses of 26.4 mg/day and Zopiclone dose of 0.22 mg/24 hour were required. In the second six-weeks of study numbers 24-hour effective Zopiclone doses increased to 34.8 mg/day and Zopiclone doses of 2.1 mg/24 hour were also required (Fig. 5). The average daily effective dose of Ozone-Based Therapy for patients receiving the combination of Zopiclone and ozone-based therapy was 0.5 mg/day in patients with moderate pain (0.3 mg/day was the average daily effective dose in all patients with moderate pain who received all three drugs in the combination; other words, it was equivalent to 2.1 mg/day of Zopiclone). This also represents an additional dose of Zopiclone equivalent to 3.67 mg/day of ZM-2.2. In the first and second six-weeks of all studies an additional Ozone-Based product was added at no charge. The average effective dose of Zopiclone in the first six weeks of all 12-week and 18-week studies was increased to 3.4 mg/day for moderate pain. Therefore, the average daily effective dose of Ozone-Based Therapy was increased by approximately 0.43 mg/day in all studies. The combination of Zopiclone with Acetazolamide (Ozone plus Zopiclone) was prescribed at doses of 0.4 mg/day for moderate pain (0.08 was the average daily effective dose in all patients with moderate pain who received all three drugs in the combination; other words, it was equivalent to 0.12 mg/day of Acetazolamide). This product was added at no charge in all studies. The daily effective doses of Zopiclone in all studies increased to 2.12 mg/24 hours for moderate pain the first six weeks and to 2.33 mg/day in all studies the subsequent 18 weeks. The combination of Zopiclone and Ozone Acetazolamide (Ozone plus Zopiclone or ZM-2.2 Acetazolamide) was prescribed in the dose range of 5.7 mg/24 hours for analgesic efficacy in the first clinical studies. For total number of 24-hour effective Zopiclone doses 2.4 mg/24 hours, the of Acetazolamide and Ozone were 1.7 mg/d in the first clinical study and to 2.4 mg/d in the second clinical studies (total dose 0.64 mg/24 hours). In the studies with Ozone-based therapy (total effective dose=3.8 mg/24 hours), Acetazolamide and Ozone were replaced with.
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